Anti-CD33 antibody agents are provided, including anti-CD33 antibody agents in the form of IgG-scFv. Various methods, and reagents related thereto, are also provided, including, for example, those intended for the detection, prevention and/or therapeutic treatment of CD33 related diseases, especially leukemias such as AML. [Selection diagram] Figure 1AIgG-scFvの形式の抗CD33抗体剤を含む、抗CD33抗体剤が提供される。様々な方法、およびそれに関連する試薬も提供され、例えば、CD33関連疾患、特に例えばAMLなどの白血病の検出、予防および/または治療的処置を目的としたものが含まれる。【選択図】図1A