A method of in vivo sensor recalibration includes implanting a sensor at an implantation site in a living body taking a sensor reading with the implanted sensor taking a first electrical reading across biological material adjacent the implanted sensor taking a second electrical reading across biological material adjacent the implanted sensor subsequent in time to the taking of the first electrical reading comparing the first electrical reading with the second electrical reading and recalibrating the sensor based on the comparison of the first electrical reading to the second electrical reading.