Jeffrey Schwartz,Ellen S. Gawalt,Michael J. Avaltroni
申请号：
US13349367
公开号：
US08993117B2
申请日:
2012.01.12
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Phosphorus-based coatings having a plurality of phosphate moieties, a plurality of phosphonate moieties, or both, covalently bonded to an oxide surface of an implantable substrate exhibiting one or more of the following characteristics: (a) the surface phosphorus-containing group density of the coated regions of the substrate is at least about 0.1 nmol/cm2 (b) the phosphorus-based coating has a thickness of less than about 10 nm or (c) the surface phosphorus-containing group density of the coated regions of the substrate is equal to or greater than the surface hydroxyl group density of the oxide surface of the substrate. Implantable devices embodying the coated substrates are also disclosed.
