David M. KOELLE,Lichen JING,Kerry LAING,Christine JOHNSTON,Anna WALD
申请号：
US15308076
公开号：
US20170049881A1
申请日:
2015.05.01
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention provides epitopes of HSV and VZV that are cross-reactive and are useful for the prevention and treatment of alphaherpesvirus infection. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against whole virus. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing epitopes or polynucleotides encoding epitopes of the invention provide effectively targeted vaccines for prevention and treatment of alphaherpesvirus infection.
