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CONJUGUÉS D'ÉNÉDIYNE
专利权人:
Synaffix B.V.
发明人:
申请号:
EP18811305.4
公开号:
EP3720504A1
申请日:
2018.12.06
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
wherein R12═C1-3-alkyl, the wavy line indicates the connection to the remainder of the cytotoxin, and wherein D is conjugated to (L4)q by replacing the amine H atom, and to conjugates obtainable by reacting the compound according to the invention with a protein comprising a click probe F capable of reacting with click probe Q in a click reaction. The invention further relates to a bioconjugate according to general structure (2): Pr-[(L6)-Z-(L1)n-(L2)o-(L3)p-(L4)q-D]xx (2), wherein Z is a connecting group that is formed in a click reaction, L6 is a linker that links Z to Pr and Pr is a (glyco)protein.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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