BOEHRINGER INGELHEIM INTERNATIONAL GMBH;BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG
发明人:
WERNER RALL,CHRISTIAN KULINNA,JUERGEN SCHNAUBELT,PETER SIEGER,RAINER SOYKA
申请号：
PT12155662
公开号：
PT2508521E
申请日:
2004.10.12
申请国别(地区):
PT
年份:
2016
代理人:
摘要：
An improved process for preparing 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline and related aminocrotonyl compounds and the preparation of a suitable salt of 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline for use as a pharmaceutically active substance.
