An object of the present invention is to provide a hollow fiber membrane blood purification apparatus that improves the antioxidant performance and has good water permeability performance, blood compatibility performance, and economic rationality. The present invention is a hollow fiber membrane-type blood purification device in which a hollow fiber membrane is filled in a container, the hollow fiber membrane comprising a hydrophobic polymer, a hydrophilic polymer and a fat-soluble vitamin, When the divided component located at the extreme end is divided into 5 parts in the length direction and the trunk end is used, the fat-soluble vitamin amount present in at least one trunk end is the amount of the fat-soluble vitamin present in all the divided components. There is provided a hollow fiber membrane-type blood purification apparatus having a maximum amount of fat-soluble vitamin per 1 m2 of hollow fiber membrane inner surface at the end of at least one body and not less than 20 mg / m2 and not more than 300 mg / m2.本発明の目的は、抗酸化性能を向上させ、かつ良好な透水性能及び血液適合性能、経済合理性を有する中空糸膜型血液浄化装置を提供することである。 本発明は、中空糸膜を容器に充填した中空糸膜型血液浄化装置であって、該中空糸膜は、疎水性高分子、親水性高分子及び脂溶性ビタミンを含み、中空糸膜束を長さ方向に５分割し、最端部に位置する分割成分を胴端部とした際に、少なくとも一方の胴端部に存在する脂溶性ビタミン量が全分割成分に存在する脂溶性ビタミン量の中で最大であり、かつ該少なくとも一方の胴端部の中空糸膜内表面１ｍ２あたりの脂溶性ビタミン量が２０ｍｇ／ｍ２以上３００ｍｇ／ｍ２以下である、中空糸膜型血液浄化装置を提供する。
