The present invention relates to a method for producing encapsulated liquid oxygen to maintain blood homeostasis is disclosed. The composition contains a carrier, encapsulated nano-bubbles with one or more gases, preferably liquid oxygen. The methods and compositions may be administered to a patient to deliver liquid oxygen to the patient's blood supply or directly to a tissue in need of liquid oxygen. The methods and compositions are also meant to eliminate carbon dioxide from blood. The compositions may be administered via injection or as a continuous infusion to a patient in an effective amount to increase oxygen concentration in the patient's blood and/or one or more tissues or organs. The encapsulated liquid oxygen may be administered alone or in combination with other treatments as an adjunctive therapy.
