The present invention relates to the use of phytocannabinoids in the treatment of cancer. More particularly it relates to the use of phytocannabinoids in the treatment of tumour cell invasion and cell migration or metastases. Cancers, where invasion and cell migration plays a key role in prognosis include brain tumours, more particularly gliomas, and most particularly Glioblastoma multiforme (GBM) and breast cancers.The phytocannabinoids tetrahydrocannabivarin (THCV) and cannabidivarin (CBDV) alone or in combination with each other and/ or other phytocannabinoids, particularly cannabidiol (CBD), tetrahydrocannabinol (THC) and cannabigerol (CBG) or their respective acids are of particular use.本發明係關於植物大麻素於癌症治療之用途。更特別地,其關於植物大麻素於腫瘤細胞侵犯及細胞移動或轉移之治療的用途。癌症,其中侵犯及細胞移動在在預後中扮演關鍵角色,包括腦瘤,更特別是神經膠質瘤,且最特別是多形性膠質母細胞瘤(GBM)及乳癌。植物大麻素四氫次大麻二酚(THCV)及次大麻二酚(CBDV)單獨或與彼此及/或與其他植物大麻素,特別是大麻二酚(CBD)、四氫大麻酚(THC)及大麻萜酚(CBG)或其對應酸組合係特別具有用途。
