ZACK, Donald,JASKULA-RANGA, Vinod,WELSBIE, Derek S.
申请号:
CL2019000025
公开号:
CL2019000025A1
申请日:
2019.01.04
申请国别(地区):
CL
年份:
2019
代理人:
摘要:
1. All materials contained in this document are:The composition described and M AMP; EACUTE; all of these include improvements to the RISPR system (for example,CRISPR-PROTE AMP; IACUTE; NA Associate (CAS) 9 (CRISPR-CAS9);(CRISPR sin CAS9). These components may include changes to regional and provincial, Oacute and H1 advocates.ADEM AMP; AACUTE; S changed to UTR 5 AMP; ACUTE;Different ORT AMP sequences; OACUTE; H1 salesman Logas,A new series of compact bilateral salesmen of the Convention for the Prevention of Ship Pollution II and the Convention for the Prevention of Ship Pollution III,ADICI AMP; OACUTE; Kozak consensus sequence N,Termination and Ampere Sequence; OACUTE; NAditi Amp; Oacute; N de la Expui Amp; Oacute; N Condition of the Bilateral Promotion POLII/POL III,Comments more than a month agoOr a combination of both Other aspects of the invention: Oacute; N involves from CAS9 to TRAV AMP; EACUTE; S involves the merger of CI AMP; OACUTE; N involves the post-treatment of cell cycle.Target design and amp; Ntilde; by Ingenier Amp; IACUTE; Gene and amp; EACUTE; TICA; so that the core can be added without isolating DNA.Self-Translating Self-Reviewing Website; Oacute; n.And modify N-terminal to modulate average lifetime; LT; / P GT;<;p>;LA MATERIA AQUÍ; DESCRITA PROPORCIONA COMPOSICIONES Y MÉ;TODOS QUE COMPRENDEN MEJORAS DE UN SISTEMA CRISPR (POR EJEMPLO, CRISPR-PROTEÍ;NA ASOCIADA (CAS) 9 (SISTEMA CRISPR-CAS9, SISTEMAS CRISPR SIN CAS9). TALES COMPOSICIONES PUEDEN COMPRENDER MODIFICACIONES EN LA REGIÓ;N PROMOTORA H1, ADEMÁ;S DE MODIFICACIONES EN UTR 5´;, DIFERENTES SECUENCIAS ORTÓ;LOGAS DEL PROMOTOR H1, NUEVAS SECUENCIAS DEL PROMOTOR BIDIRECCIONAL COMPACTO CON ACTIVIDAD TANTO POL II COMO POL III, ADICIÓ;N DE SECUENCIAS DE CONSENSO DE KOZAK, SECUENCIAS DE TERMINACIÓ;N, ADICIÓ;N DE LA EXPRESIÓ;N CONDICIONAL DEL PROMOTOR BIDIRECCIONAL POL II/POL III, ADICIÓ;N DE UNA SECUENCIA MOLDE DONANT