ПИЛГРЕН Мария (CH),ПФАЙФЕР Андреа (CH),МУС Андреас (CH),УОТТС Райн (US)
申请号：
RU2012133155/10
公开号：
RU2012133155A
申请日:
2012.08.02
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A pharmaceutical composition for treating an ocular disease associated with amyloid-beta-related pathological disorders or changes in the tissues of the visual system, comprising a therapeutically effective amount of an antibody or a functionally active fragment thereof including light chain CDR1 having the amino acid sequence of SEQ ID NO: 21； Light chain CDR2 having the amino acid sequence of SEQ ID NO: 22； CDR3 light chain having the amino acid sequence of SEQ ID NO: 23； Heavy chain CDR1 having the amino acid sequence of SEQ ID NO: 24； A heavy chain CDR2 having the amino acid sequence of SEQ ID NO: 25； and a heavy chain CDR3 having the amino acid sequence of SEQ ID NO: 26.2. The pharmaceutical composition according to claim 1, wherein the ocular disease associated with pathological disorders or changes in the tissues of the visual system associated with amyloid-beta is selected from the group consisting of cortical visual failure, glaucoma, primary retinal degeneration, macular degeneration, senile plaques optic nerve, optic neuropathy, retrobulbar neuritis, cataract, ocular amyloidosis and ethmoid corneal dystrophy. 3. The pharmaceutical composition according to claim 2, wherein the ocular disease associated with pathological disorders or changes in the tissues of the visual system associated with amyloid-beta is glaucoma. The pharmaceutical composition according to claim 3, in which glaucoma is selected from the group consisting of chronic open-angle glaucoma, acute angle-closure glaucoma, glaucoma of a mixed or combined mechanism, glaucoma, not1. Фармацевтическая композиция для лечения глазного заболевания, ассоциированного со связанными с амилоидом-бета патологическими нарушениями или изменениями в тканях зрительной системы, включающая терапевтически эффективное количествоантитела или его функционально активного фрагмента, включающего CDR1 легкой цепи, имеющую аминокислотную последовательность SEQ ID NO:21； CDR2 легкой цепи, имеющую аминокислотную последов
