David A. Scheinberg,Michael McDevitt,Christophe Antczak,Debjit Chattopadhyay,Rena May,Jón Njardarson,Mark Reid Philips
申请号：
US11989672
公开号：
US08540965B2
申请日:
2006.07.31
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention provides soluble single wall nanotube constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble single wall carbon nanotube via a DNA or other oligomer platform attached to the single wall carbon nanotube. These soluble single wall carbon nanotube constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble single wall carbon nanotube constructs.
