Chao-Wei Hwang,Hala J. Tomey,Jon R. Rosar,Robert C. Matteson,George L/ Coles,Jason J. Benkoski,Morgana M. Trexler
申请号：
US14179835
公开号：
US20140188213A1
申请日:
2014.02.13
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.
