Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing the compounds represented by formula I.本文揭示用於治療哺乳動物病毒性感染之核苷衍生物之胺基磷酸酯前藥，其為化合物、該化合物之立體異構物、鹽(酸或鹼加成鹽)、水合物、溶劑合物或其結晶形態，其由以下結構表示：本發明亦揭示各利用由式I表示之化合物之治療方法、用途及製備方法。
