A PHOTOSENSITIZER-LOADED CALCIUM CARBONATE HYBRID NANOPARTICLE, A PREPARATION METHOD THEREOF AND A COMPOSITION FOR ULTRASOUND CONTRAST IMAGING AND PHOTODYNAMIC THERAPY COMPRISING THE SAME
경희대학교 산학협력단;UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
发明人:
LEE, SANG CHEON,이상천,PARK, DONG JIN,박동진,MIN, KYUNG HYUN,민경현,LEE, SANG CHEONKR,PARK, DONG JINKR,MIN, KYUNG HYUNKR
申请号：
KR1020140095018
公开号：
KR1020160013474A
申请日:
2014.07.25
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to a photosensitizer-loaded calcium carbonate hybrid nanoparticle, a method for manufacturing the same, and a composition for ultrasound contrast imaging and photodynamic therapy comprising the same and, more specifically, to a photosensitizer-loaded calcium carbonate hybrid nanoparticle comprising a photosensitizer-loaded calcium carbonate core and a polymer shell, not discharging a photosensitizer existing in the calcium carbonate core by being stable in a blood flow without dissolution of calcium carbonate, generating carbon dioxide according to dissolution of calcium carbonate by being dissolved in acid pH of endosome and lysosome in cancer tissues and cells after targeting, and simultaneously performing ultrasound contrast imaging and photodynamic therapy by inducing discharge of the loaded photosensitizer； to a manufacturing method thereof； and to a composition for ultrasound contrast imaging and photodynamic therapy comprising the same. The photosensitizer-loaded calcium carbonate hybrid nanoparticle comprises a photosensitizer, and a copolymer composed of a non-ionic hydrophilic polymer part and an ionic polymer part. The photosensitizer-loaded calcium carbonate and the ionic polymer part of the copolymer form a core part. The non-ionic hydrophilic polymer part forms a shell part.본 발명은 광감작제 담지 탄산칼슘 복합 나노입자, 이의 제조방법 및 이를 포함하는 초음파 조영 및 광역학 치료용 조성물에 관한 것으로, 더욱 상세하게는 광감작제가 담지된 탄산칼슘 코어 및 고분자 쉘로 구성된 탄산칼슘 복합 나노 입자로서, 혈류 내에서는 안정한 상태로 탄산칼슘의 용해가 일어나지 않아 탄산칼슘 코어 내에 존재하는 광감작제의 방출이 일어나지 않고, 표적화 후 암조직 및 세포 내 엔도좀/라이소좀의 산성 pH에서 용해되어 탄산칼슘 용해에 따라 이산화탄소를 발생시키고 담지된 광감작제의 방출을 유도하여 초음파 조영과 동시에 광역학 치료를 병행할 수 있는 광감작제 담지 탄산칼슘 복합 나노입자, 이의 제조방법 및 이를 포함하는 초음파 조영 및 광역학 치료용 조성물에 관한 것이다.
