The present invention discloses a UAV automatic spray system, comprising an unmanned aerial vehicle (UAV), a wind direction and speed meter and a main control device. The UAV automatic sprinkler system uses the UAV to determine a spray target region with the UAV flying to a plurality of positioning point, the UAV spraying with a predetermined spray width, the wind direction and speed meter measuring a wind direction and speed information simultaneously, the main control device calculating an optimum spray route according to the spray target region, the predetermined spray width and the wind direction and speed information. By the above means, the present invention spray agricultural chemicals and fertilizers automatically and precisely using the UAV, thereby saving the chemicals, manpower and time costs.本發明揭露一種無人飛行器自動化噴灑系統,係具有一無人飛行器、一風向風速裝置及一主控裝置,本系統利用該無人飛行器預先飛行至多數個噴灑範圍定位點定位而得出一噴灑作業區域範圍,該無人飛行器係以一預定的噴灑幅寬來噴灑,該風向風速裝置係即時地測量該作業區域的一風向風速資料,該主控裝置係根據該噴灑作業區域範圍、該噴灑幅寬及該風向風速資料而計算出一最佳噴灑路線,接著,該主控裝置遙控該無人飛行器依循該最佳噴灑路線自動化地飛行。藉此,自動而精確地運用無人飛行器來噴灑農藥或肥料,達到節省藥劑、人力及時間成本的目的。100‧‧‧無人飛行器自動化噴灑系統1‧‧‧無人飛行器16‧‧‧農藥儲存構件162‧‧‧噴灑流量控制器17‧‧‧聲納構件2‧‧‧風向風速裝置3‧‧‧主控裝置4‧‧‧後台裝置N‧‧‧網路