Technical result of the invention is achieved by practical use of effective formulation containing accessible components based on biologically active agents of natural origin, which has a comprehensive effect on dental tissues and can be recommended for periodontium prophylaxis and treatment as well as caries and non-carious affections prophylaxis. The main purpose of this invention was to elaborate high-efficiency formulation for prophylaxis of dental diseases of teeth and soft tissues of oral cavity in which synergist medications could heighten effect of each other attaining high therapeutic effect and results mentioned above. Medicine for dental diseases prophylaxis contains orally acceptable active and inert components. As active components there are used about 0.3% to 2.2% by weight of lipid concentrate of kelp, 0.5 % to 5.0 % by weight of kelp salt, 0.5% to 4.0 % by weight of dry extract of liquorice root, 0.01% to 0.25% by weight of one or more essential oils to enhance organoleptic properties, and 0.1% to 3.5 % by weight of anticaries mineral adjunct.