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POLYMER CONJUGATES OF GLP-1
专利权人:
发明人:
申请号:
EP06847728.0
公开号:
EP1968644B1
申请日:
2006.12.18
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
Conjugates of a GLP-1 moiety may be covalently attached to one or more water-soluble polymers. For instance, a GLP-1 polymer conjugate may include a GLP-1 moiety releasably attached at its N-terminus to a water-soluble polymer. The GLP-1 polymer conjugate may include a GLP-1 moiety covalently attached to a water-soluble polymer, wherein the GLP-11I moiety possesses an N-methyl substituent. The GLP-1 polymer conjugate may include a GLP-1 moiety covalently attached at a polymer attachment site to a water-soluble polymer, wherein the GLP-1 moiety is glycosylated at a site separate from the polymer attachment site.
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