A drink dispenser with detachable fizz infuser including drink bottle, characterized by and comprising a base, a main body, a main body support, a top cap, an exiting gas driving device, a gas exiting device, a gas transfer device, a gas inlet device, and a CO2 cylinder. The compartment for the CO2 cylinder in the said main body has an inlet and an outlet as well as a side cap that is connected to the main body and pin-jointed with the inlet and the outlet. With this structure, the gas exiting device can be activated simply by pressing the exiting gas driving device. Gas flows from the CO2 cylinder, enters the gas transfer device and the gas inlet device, and ends up in the drink bottle. The operation is simple and easy. The configuration of the safety device eliminates potential safety hazards and ensures safety by preventing the drink bottles from being over-pressurized. Provision of the side cap facilitates convenient replacement of the CO2 cylinder.