Sunil Krishnan,Parmeswaran Diagaradjane,Jon Alexander Schwartz,James Chunjay Wang
申请号：
US13742446
公开号：
US20130197295A1
申请日:
2013.01.16
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Methods are provided for the treatment of diseases and disorders using systematically-introduced nanoparticles to create a focused localized hyperthermia in a target area to enhance the effect of additional treatment therapies such as ionizing radiation. Advantages include an enhancement of the therapeutic effect of other therapies by increasing perfusion or reducing hypoxia in the treatment area, further, the methods herein may also result in the disruption of the vasculature, which provide further impetus for such treatments, singly and in combination with conventional therapies such as chemotherapy and radiation therapy. Methods for treating a target area may comprise systemically introducing nanoparticles into an organism allowing the nanoparticles to preferentially accumulate in the target area, applying an external energy where the nanoparticles are adapted to transduce at least a portion of the external energy into a heat energy so as to create a focused localized hyperthermia and applying a subsequent additional therapy.
