Glucose deprivation is an attractive strategy in cancer research andtreatment. Cancer cells upregulate glucoseuptake and metabolism for maintaining accelerated growth and proliferationrates. Specifically blocking these processes is likely toprovide new insights to the role of glucose transport and metabolism intumorigenesis, as well as in apoptosis. As solid tumorsoutgrow the surrounding vasculature, they encounter microenvironments with alimited supply of nutrients leading to a glucosedeprived environment in some regions of the tumor. Cancer cells living in theglucose deprived environment undergo changes toprevent glucose deprivation-induced apoptosis. Knowing how cancer cells evadeapoptosis induction is also likely to yieldvaluable information and knowledge of how to overcome the resistance toapoptosis induction in cancer cells. Disclosed herein arenovel anticancer compounds that inhibit basal glucose transport, resulting intumor suppression and new methods for the study ofglucose deprivation in animal cancer research.
