System and method for aiding communication for subjects suffering from paralysis of muscles controlled by peripheral nervous system are disclosed. A method for aiding communication for said subjects includes capturing, from a plurality of sensors, sensor data generated based on an interaction of a subject with an interactive UI. The plurality of sensors includes one or more body-parts movement tracking sensors for tracking motion of body-parts of the subject and one or more physiological signal sensors for monitoring physiological signals generated from the subject during the interaction. A plurality of model parameters indicative of characteristics of the subject related to the interaction are determined based on the sensor data. The navigation at the interactive UI is controlled on the plurality of model parameters.
