A recombinant polypeptide comprising (i) a fragment of a High Molecular Weight Melanoma-Associated Antigen (HMW-MAA) protein encoded by a nucleotide sequence selected from SEQ ID NOs: 21-23, or a polypeptide having greater than 97% sequence identity thereto, and (ii) a PEST sequence from Listeria, or a recombinant Listeria comprising said recombinant polypeptide, for use in inducing an immune response to a cancer or tumor that does not express HMW-MAA, for use in delaying the progression of a cancer or tumor that does not express HMW-MAA, or for use in treating a cancer or tumor that does not express HMW-MAA.
