聯芳基丙酸及其作為醫藥品之用途农业专利-农业学术服务平台

发明人:: RUF, SVEN,鲁夫　史文,魯夫　史文,SADOWSKI, THORSTEN,沙多史奇　托尔斯滕,沙多史奇　托爾斯滕,WIRTH, KLAUS,维尔特　克劳斯,維爾特　克勞斯,SCHREUDER, HERMAN,史锥德　赫尔曼,史錐德　赫爾曼,BUNING, CHRISTIAN,布宁　克里斯帝安,布寧　克里斯帝安,KALLUS, CHRISTOPHER,卡卢斯　克里斯多夫,卡盧斯　克里斯多夫,鲁夫史文,魯夫史文,沙多史奇托尔斯滕,沙多史奇托爾斯滕,维尔特克劳斯,維爾特克勞斯,史锥德赫尔曼,史錐德赫爾曼,布宁克里斯帝安,布寧克里斯帝安,卡卢斯克里斯多夫,卡盧斯克里斯多夫

摘要：: The present invention relates to compounds of the formula I,wherein X, R, R1, R2, D, E1, E2, E3, E4, G1, G2, G3 and G4 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.本發明係關於式I化合物，其中X、R、R1、R2、D、E1、E2、E3、E4、G1、G2、G3及G4具有在申請專利範圍中所指出之意義，其係有價值的醫藥活性化合物。其係組織蛋白酶A之抑制劑且可以用於治療疾病例如動脈粥樣硬化症、心臟衰竭、腎病、肝病或發炎性疾病。本發明還關於式I化合物之製備方法、其用途及含其之醫藥組成物。