The present invention provides the novel use of peroxidases, lactoferrin, lysozymes and immunoglobulins (used alone and/or combined) for the control of microbial biofilms after the action of growth factors (used alone and/or combined) on the epithelial and fibroblast cells to remove micro-organism biofilms adherent on cell surfaces. The present invention also relates to the use of peroxidases, lactoferrin, lysozymes and immunoglobulins (used alone and/or combined) in combination with growth factors (used alone and/or combined) for the preparation of medicaments for the prophylaxis or therapy of infectious diseases caused by microorganisms present in biofilms adherent on cell surfaces.