JUNG, SUNG YOUB,JANG, MYUNG HYUN,SHEN, LING AI,PARK, YOUNG KYUNG,PARK, YOUNG JIN,KWON, SE CHANG
申请号：
PE0027892013
公开号：
PE07652014A1
申请日:
2012.06.07
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to a Peptide derived from oxintomodulina Active glp-1 receptor and Glucagon Receptor comprising the amino acid sequence of Formula 1 which is gtftsd X1 x2 R1 - - - - - - - X3 X4 X5 X6 X7 x8 X9 X10 - - - - - - - X14 X11, X12 and X13 x15 - x16 x18 x19 - Concept - - - - - X20 X21 x22 X23 x24 - R2, where R1 is histidine. Minohistidilo, 4 - imidazoacetilo, among others x1 is aminoisobutirico acid, Glycine,Among others x2 is glutamic acid or glutamine or Leucine X3 is tyrosine, Serine or alanine is X4, X5 is lysine or arginine, glutamine and tyrosine is X6, X7 is Leucine or methionine aspartic or glutamic acid X8, X9 is among others X10 is Serine, glutamine, Lysine, among others x11 is alanine, Vali NA, among others X12 is Serine, Valine, among others X13 is Glutamine, Lysine,Among others, x14 is Aspartic acid, Leucine, among others x15 is phenylalanine, isoleucine x16 is, among others, x17 is alanine, cysteine, x18 is among others tryptophan x19 is Serine, isoleucine, among others X20 is Lysine, methionine, among others is X21 x22 is alanine, asparagine, threonine between X-23 is cysteine, otherAmong others, x24 is a Peptide of 2 to 10 amino R2 is SEQ ID number: 32, 33, 34, 35, 36, 37 or Suppressed. It also relates to a Pharmaceutical composition useful in the treatment of ObesitySE REFIERE A UN PEPTIDO DERIVADO DE OXINTOMODULINA QUE ACTIVA EL RECEPTOR DE GLP-1 Y EL RECEPTOR DE GLUCAGON QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE FORMULA 1 QUE ES R1-X1-X2-GTFTSD-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15-X16-X17-X18-X19-X20-X21-X22-X23-X24-R2, DONDE R1 ES HISTIDINA, DESAMINOHISTIDILO, 4-IMIDAZOACETILO, ENTRE OTROS X1 ES ACIDO AMINOISOBUTIRICO, GLICINA, ENTRE OTROS X2 ES ACIDO GLUTAMICO O GLUTAMINA X3 ES LEUCINA O TIROSINA X4 ES SERINA O ALANINA X5 ES LISINA O ARGININA X6 ES GLUTAMINA O TIROSINA X7 ES LEUCINA O METIONINA X8 ES ACIDO ASPARTICO O GLUTAMICO X9 ES SERINA, ENTRE OTROS X10 ES GLUTAMINA, LISINA, ENTRE OTROS X11 ES ALANINA, VALINA, ENTRE OTROS X12 ES SE
