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ÉMULSIONS OPTIMISÉES DE FLUOROCARBONE POUR SUBSTITUTS SANGUINS ET AUTRES USAGES THÉRAPEUTIQUES
专利权人:
ALLIANCE PHARMACEUTICAL CORP
发明人:
WEERS, JEFFREY,KLEIN, DAVID,JOHNSON, CINDY
申请号:
EP07795229
公开号:
EP2034959A4
申请日:
2007.05.22
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
The present invention is directed to a stable fluorocarbon emulsion having a continuous aqueous phase and discontinuous fluorocarbon phase comprising two fluorocarbons and surprisingly demonstrates that perfluorodecyl bromide is as effective in stabilizing perfluorooctyl bromide emulsions of certain concentrations than much more highly concentrated perfluorooctyl bromide/perfluorodecyl bromide emulsions without the significant problems experienced in higher concentrated emulsions such as longer organ retention times, formation of PFDB crystals, larger emulsion particles, manufacturing problems and inability of repeat dosing inherent with higher concentrations of perfluorodecyl bromide.
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