Provided herein are methods of preventing and treating polybacterial infections comprising administering an effective amount of an antibody or antigen-binding fragment thereof that specifically binds to an epitope produced by at least one of the bacterium in the polybacterial infection. For example, an antibody that specifically binds to Staphylococcus aureus alpha toxin can be administered to a patient with a polybacterial infection comprising Staphylococcus aureus and Pseudomonas aeruginosa to inhibit the growth of Pseudomonas aeruginosa.本文提供預防及治療多重細菌感染之方法，其包括投與有效量之特異性結合至該多重細菌感染中至少一種細菌所產生之抗原決定基之抗體或其抗原結合片段。例如，可將特異性結合至金黃色葡萄球菌(Staphylococcus aureus)α毒素之抗體投與至患有多重細菌感染(包括金黃色葡萄球菌及綠膿桿菌(Pseudomonas aeruginosa))之患者，以抑制綠膿桿菌之生長。
