COMBINATION THERAPY FOR TREATING MALIGNANCIES

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专利权人:

AGIOS PHARMACEUTICALS; INC.;AGIOS PHARMACEUTICALS, INC.;CELGENE CORPORATION

发明人:

AGRESTA, Samuel,VISWANADHAN, Krishnan,DIMARTINO, Jorge,CHOPRA, Vivek Saroj,MACBETH, Kyle,KNIGHT, Robert,KENVIN, Laurie,XU, Qiang

申请号：

SG11201803091P

公开号：

SG11201803091PA

申请日:

2016.10.14

申请国别(地区):

SG

年份:

2018

代理人:

摘要：

Provided are methods and compositions for treating hematological malignancies in patients carrying an IDH1 mutation using a combination of an inhibitor of mutant IDH1 enzyme, (S)-N-((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide, or a pharmaceutically acceptable salt thereof (COMPOUND 2) and a DNA demethylating agent.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/