BACKUS KERIANN MARIE,DAVIS BENJAMIN OF UNIVERSITY,BARRY III CLIFTON B,BOSHOFF HELENA
申请号：
IN3177/CHENP/2012
公开号：
IN2012CN03177A
申请日:
2012.04.09
申请国别(地区):
IN
年份:
2013
代理人:
摘要：
A method for determining the presence of mycobacteria species in an organism or biological sample, the method comprising adding to the organism or biological sample a probe molecule comprising a substrate and a label, which probe molecule can be incorporated into mycobacteria, a presence of mycobacteria being determined by a detector responsive to the presence of the label, optionally after applying a stimulus suitable probe molecules include compounds comprising a label and a substrate, which label is can be detected by a detector responsive to the presence of the label, optionally after applying a stimulus, charcterised by compound being able to engage with the active site of Antigen 85B (Ag85B) such that it can form simultaneous hydrogen bonds with two or more amino acids in the active site selected from Arg 43, Trp 264, Serl26, His 262 and Leu 42, or the corresponding amino acids in Antigen 85 A (Ag85A) or Antigen 85C (Ag85C), at least one of which is with Serl26.
