PROBLEM TO BE SOLVED: To provide a new compound having an action as a strong mGluR2 positive modulator and being useful as a therapeutic agent of mental illness and neurodegenerative disease in which a mGluR2 of schizophrenia, anxiety disorder, or the like is involved.SOLUTION: A compound of formula (I) or a pharmaceutically acceptable salt thereof is provided [wherein R1 represents a 1-10C alkyl or the like, X represents a hydrogen atom, a halogen or the like, Y represents a 1-6C alkyl or the like, n represents an integer of 0 to 4, Z represents -L1-A-L2-B1 or the like, L1 represents a single bond or the like, A represents an arylene or the like, L2 represents a single bond or the like, and B1 represents an aryl or the like].COPYRIGHT: (C)2013,JPO&INPIT【課題】強いmGluR2ポジティブモジュレーターとしての作用を有し、統合失調症、不安障害等のmGluR2が関与する精神疾患及び神経変性疾患の治療剤として有用な新規化合物を提供。【解決手段】式(I)の化合物又はその製薬学的に許容される塩[式中、R1はC1-10アルキル等を表し、Xは水素原子、ハロゲン等を表し、YはC1-6アルキル等を表し、nは0~4の整数を表し、Zは、-L1-A-L2-B1等を表し、L1は単結合等を表し、Aはアリーレン等を表し、L2は単結合等を表し、B1はアリール等を表す。]【選択図】なし
