Disclosed is a formulation for modulating inflammation associated with damage to connective tissue in humans and animals, comprising: one or more avocado/soybean unsaponifiables； an aminosugar； and a glycosaminoglycan component, wherein the glycosaminoglycan component is selected from the group consisting of: chondroitin, hyaluronic acid, glucuronic acid, iduronic acid, keratin sulfate, heparan sulfate, dermatin sulfate, and fragments, salts, and mixtures thereof； and wherein the amino sugar is selected from the group consisting of: glucosamine, glucosamine hydrochloride, glucosamine sulfate, glucosamine phosphate, and N-acetylglucosamine and salts and/or mixtures thereof
