PROBLEM TO BE SOLVED: To provide compositions for preventing and treating HIV infection.SOLUTION: The invention relates to an antibody against CD4, which comprises a heavy chain variable region amino acid sequence and a light chain variable region amino acid sequence, each comprising CDR1, CDR2, and CDR3 of specific sequences, and heavy- and light chain constant regions of specific amino acid sequences. In certain embodiments, the antibody binds to a region around domain 1 of CD4 molecule, the antibody activates resting CD4+ cells upon crosslinking, the antibody binds to a region around CDR2 in domain 1 of CD4 molecule, the antibody has an N-glycosylation site in the heavy chain variable region, the antibody has an asparagine (Asn) residue located in CDR3 of the heavy chain variable region that is bound to a sugar molecule, the antibody is a monoclonal antibody, polyclonal antibody or a combination thereof, and the antibody is a humanized monoclonal antibody.SELECTED DRAWING: NoneCOPYRIGHT: (C)2020,JPO&INPIT【課題】ＨＩＶ感染の予防、処置のための組成物の提供。【解決手段】ＣＤ４分子に対する抗体であって、抗体が特定配列のＣＤＲ１、ＣＤＲ２、ＣＤＲ３を有する重鎖及び軽鎖可変領域アミノ酸配列と特定配列の重鎖及び軽鎖定常領域アミノ酸配列を有する抗体。抗体が、ＣＤ４分子のドメイン１周りの領域に結合する抗体。抗体が、架橋の際、休止ＣＤ４＋細胞を活性化する抗体。抗体が、ＣＤ４分子のドメイン１におけるＣＤＲ２領域周りの領域に結合する抗体。抗体が、重鎖可変領域にＮ－グリコシル化部位を有する抗体。抗体が、糖分子に結合する重鎖可変領域のＣＤＲ３に局在化するアスパラギン（Ａｓｎ）残基を有する抗体。抗体が、モノクローナル抗体、ポリクローナル抗体、又はそれらの組合せである抗体。抗体がヒト化モノクローナル抗体である抗体。【選択図】なし
