The mode being packed in capsule for example, by the polymer that wherein active constituent is controlled the tablet released, granule or fine grained agent and forms gel, the present invention provides a kind of wherein active constituents to be controlled the controlled release preparation released, and this controlled release preparation is delayed and delaying or slowing down migration in the gastrointestinal tract releases active constituent. The tablet, granule or fine grained agent have the controlled release coating layer being formed on the core particle containing active constituent.通過例如將其中活性成分被控制釋出的片劑、顆粒劑或細顆粒劑以及形成凝膠的聚合物包入膠囊中的方式，本發明提供了一種其中活性成分被控制釋出的控釋製劑，這種控釋製劑通過延緩或者减緩在胃腸道中的遷移而延時釋出活性成分。所述片劑、顆粒劑或細顆粒劑具有形成在含有活性成分的核芯顆粒上的控釋包衣層。
