Disclosed herein is the use of a compound represented by a compound of formula (III), wherein the substituents are as defined in the specification in the manufacture of a medicament for suppressing a peripheral nerve disorder induced by an anti-cancer agents (preferably selected from paclitaxel, docetaxel, vincristine, vinblastine, cisplatin, carboplatin, oxaliplatin and bortezomib). Particularly preferred compoumds include: ethyl(6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]-1-cyclohexene-1-carboxylate ethyl(3S)-3-[N-(2-chloro-4-fluorophenyl)sulfamoyl]-3,6-dihydro-2H-pyran-4-carboxylate ethyl(-)-6-[(2-chloro-4-fluorobenzyl)sulfonyl]-1-cyclohexene-1-carboxylate ethyl(+)-6-[(2-chloro-4-fluorobenzyl)sulfonyl]-1-cyclohexene-1-carboxylate.
