ANTIBODIES AGAINST HUMAN TWEAK AND USES THEREOF

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专利权人:

F. HOFFMANN-LA ROCHE AG

发明人:

BAEHNER, MONIKA,KNOETGEN, HENDRIK,NIEWOEHNER, JENS

申请号：

NZ59434710

公开号：

NZ594347A

申请日:

2010.03.30

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed is an antibody binding to human TWEAK, characterized by comprising CDR1H of SEQ ID NO:22, CDR2H of SEQ ID NO:23, CDR3H of SEQ ID NO:24 and CDR1L of SEQ ID NO:18, CDR2L of SEQ ID NO:19, CDR3L of SEQ ID NO:20, or by comprising CDR1H of SEQ ID NO:22, CDR2H of SEQ ID NO:74, CDR3H of SEQ ID NO:24 and CDR1L of SEQ ID NO:18, CDR2L of SEQ ID NO:19, CDR3L of SEQ ID NO:20, or by comprising CDR1H of SEQ ID NO:22, CDR2H of SEQ ID NO:75, CDR3H of SEQ ID NO:24 and CDR1L of SEQ ID NO:18, CDR2L of SEQ ID NO:19, CDR3L of SEQ ID NO:20. Also disclosed is the use of the antibody in the manufacture of a medicament for the treatment of cancer.

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