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附加糖鏈胰高血糖素樣肽-1胜肽
专利权人:
发明人:
KAJIHARA, YASUHIRO,梶原康宏,TSUJI, TAKASHI,辻孝,SAKAMOTO, IZUMI,坂本泉,NAMBU, YURI,南部由利,FUKAE, KAZUHIRO,深江一博,TEZUKA, KATSUNARI,手克成,ASAI, HIROAKI,朝井洋明
申请号:
TW097122564
公开号:
TWI423821B
申请日:
2008.06.17
申请国别(地区):
TW
年份:
2014
代理人:
摘要:
The present invention relates to an oligosaccharide chain added GLP-1 peptide that has higher stability in blood than that of GLP-1 and, preferably, exhibits higher activity of controlling blood-sugar levels than that of GLP-1. The present invention relates to an oligosaccharide chain added GLP-1 peptide having GLP-1 activity, wherein at least one amino acid is substituted with an oligosaccharide chain added amino acid, in:(a) GLP-1; (b) a peptide having the amino acid sequence of GLP-1 with deletion, substitution or addition of one or several amino acids; or (c) a GLP-1 analog.本發明附加糖鏈胰高血糖素樣肽-1(GLP-1)胜肽,係有關於與GLP-1相比,血中半衰期長,且顯現高血糖值抑制活性之附加糖鏈GLP-1胜肽。本發明在(a)GLP-1(b)GLP-1中被缺失置換或附加1個或數個之胺基酸之胜肽;或(c)GLP-1之同系物中其特徵為至少1個胺基酸被附加糖鏈胺基酸置換來形成具有GLP-1活性之附加糖鏈GLP-1胜肽。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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