用於cccDNA之寡核苷酸標靶策略农业专利-农业学术服务平台

发明人:: GRYAZNOV, SERGEI,格里亚兹诺夫　薛尔盖,格里亞茲諾夫　薛爾蓋,FITZGERALD, MEGAN,菲茨杰拉德　梅根,STOYCHEVA, ANTITSA DIMITROVA,史托契瓦　安缇莎,史托契瓦　安緹莎,HONG, JIN,洪　劲,洪　勁,格里亚兹诺夫薛尔盖,格里亞茲諾夫薛爾蓋,菲茨杰拉德梅根,史托契瓦安缇莎,史托契瓦安緹莎,洪劲,洪勁

摘要：: The present disclosure provides oligonucleotide compositions that target the covalently closed circular (ccc) DNA of hepatitis B virus (HBV). Also disclosed herein are methods for treating a subject diagnosed with, or suspected of having an HBV infection and/or an HBV-associated disorder, e.g., chronic hepatitis B infection, liver failure or cirrhosis and hepatocellular carcinoma.本揭露提供靶向B型肝炎病毒(HBV)之共價閉合環狀(ccc)DNA的寡核苷酸組成物。本文亦揭露用於治療經診斷患有或懷疑患有HBV感染及/或HBV相關病症(例如慢性B型肝炎感染、肝衰竭或肝硬化、及肝細胞癌)的個體之方法。