CHOU KANG-JYE,CHOU Kang-Jye,GUO HONG,GUO Hong,ASHTON PAUL,ASHTON Paul,SHIMIZU ROBERT W.,SHIMIZU Robert W.,WATSON DAVID A.,WATSON David A.
申请号：
SI200432134
公开号：
SI2233112T1
申请日:
2004.10.26
申请国别(地区):
SI
年份:
2014
代理人:
摘要：
An injectable drug delivery device includes a core containing one or more drugs and one or more polymers. The core may be surrounded by one or more polymer outer layers (referred to herein as coatings, skins, or outer layers). In certain embodiments, the device is formed by extruding or otherwise preforming a polymeric skin for a drug core. The drug core may be co-extruded with the skin, or inserted into the skin after the skin has been extruded, and possibly cured. In other embodiments, the drug core may be coated with one or more polymer coatings. These techniques may be usefully applied to fabricate devices having a wide array of drug formulations and skins that can be selected to control the release rate profile and various other properties of the drugs in the drug core ina form suitable for injection using standard or non-standard gauge needles. The device may be formed by combining at least one polymer, at least one drug, and at least one liquid solvent to form a liquid suspension or solution wherein, upon injection, such suspension or solution under goes a phase change and forms a gel. The configuration may provide for controlled release of the drug(s) for an extended period.
