Luciano Guarneri;Amedeo Leonardi;Carlo Riva;Gianni Motta;Katia Dimitrova Karamfilova;Davide Graziani;Carlo De Toma
发明人:
Amedeo Leonardi,Gianni Motta,Carlo Riva,Luciano Guarneri,Davide Graziani,Carlo De Toma,Katia Dimitrova Karamfilova
申请号：
US13180166
公开号：
US20120059015A1
申请日:
2011.07.11
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention is directed to methods of using antagonists selective for the metabotropic mGlu5 receptor to treat conditions of neuromuscular dysfunction of the lower urinary tract in a mammal. Provided are methods of treating a mammal suffering from a condition of neuromuscular dysfunction of the lower urinary tract by administering a selective mGlu5 antagonist. The selective mGlu5 antagonist may be administered alone or in combination with one or more additional therapeutic agents for treating such a condition. Also provided are methods of identifying selective mGlu5 antagonists that are useful for treating neuromuscular dysfunction of the lower urinary tract in a mammal. Methods for treating migraine and gastroesophageal reflux disease (GERD) using selective mGlu5 antagonists are also disclosed.
