Brett Granger,Guoqiang Wang,Ruichao Shen,Jing He,Yong He,Xuechao Xing,Jun Ma,Jiang Long,Bin Wang,Yat Sun Or
申请号：
US15988806
公开号：
US10450301B2
申请日:
2018.05.24
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts and esters thereof:which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcohol steatohepatitis disease (NASH).
