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ОФТАЛЬМОЛОГИЧЕСКИЕ КОМПОЗИЦИИ
专利权人:
ДЖОНСОН ЭНД ДЖОНСОН ВИЖН КЭА; ИНК. (US)
发明人:
МОЛОК Фрэнк Ф. Мл. (US),ХИТОН Джон К. (US)
申请号:
RU2013124807/15
公开号:
RU2013124807A
申请日:
2011.10.25
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A composition comprising (R) -Q- (R), wherein R is independently selected from the group consisting of sulphonates, phosphonates, carboxylates, and their ophthalmologically acceptable salts r and independently selected from H and Calkilov, Q is selected from conjugated polyaromatic hydrocarbons, having 2-3 aromatic rings and condensed polycyclic aromatic hydrocarbons containing 2-12 aromatic rings b is an integer from 1 to z where z is the number of aromatic rings in Q m is an integer from 1 to z, and the sum of m + b is not greater z R c is selected from -NRR, -CH (CHCHO) CH, -Calkilen (X), wherein X is a hydrophilic monomer selected from hydrophilic (meth) acrylates and ( meth) acrylamides, and p is an integer from 3 to 40, with the proviso that at least one said composition has a log P -2 to 5.2. A composition according to claim 1, wherein Q is a condensed polyaromatic compound having 2-6 aromatic kolets.3. A composition according to claim 1, wherein Q is a condensed polyaromatic compound having 2-3 aromatic koltsa.4. A composition according to claim 1, wherein at least one of R is selected from the group consisting of sulphonates, phosphonates, carboxylates, and their ophthalmologically acceptable soli.5. A composition according to claim 1, wherein p is an integer from 3 to 35.6. A composition according to claim 1, wherein said composition has a log P of about -1 to 2,7.7. A composition according to claim 1, wherein said composition has a log P of from about -0.7 to 1,5.8. A composition according to claim 1, wherein said hydrophilic monomer is selected from the group consisting of N, N-dimethylacrylamide, 2-hydroxyethyl methacrylate, glycerol methacrylate, 2-gidroksietilmetakrilamid, polyethyleneglycol, methacrylic acid and acrylic to1. Композиция, содержащая(R)b-Q-(R4)m,где R независимо выбрано из группы, состоящей из сульфонатов, фосфонатов, карбоксилатов и их офтальмологически приемлемых солейR2 и R3 независимо выбираются из H и C1-3 алкилов,Q выбрано из к
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