The present invention by containing rosiglitazone (Rosiglitazone) as an active ingredient, inhibit emphysema lung generation of substantial destruction and pulmonary hypertension caused by smoking and by suppressing the infiltration of inflammatory cells smoke-induced chronic obstructive pulmonary disease preventing and treating effect It will provide for a pharmaceutical composition.Rosiglitazone, smoking, chronic obstructive pulmonary disease, emphysema, pulmonary hypertension본 발명은 로지글리타존(Rosiglitazone)을 유효성분으로 함유함으로써, 흡연으로 유발된 폐기종성 폐실질 파괴의 발생과 폐동맥 고혈압을 억제하고 염증세포의 침윤을 억제시켜 흡연-유발 만성 폐쇄성 폐질환 예방 및 치료 효과를 제공하는 약제학적 조성물에 대한 것이다.