A pharmaceutical composition for oral administration wherein taste of the pharmaceutically active ingredient is masked prepared by wet granulation of a mixture of a pharmaceutically active ingredient at least one compound selected from the group consisting of magnesium aluminometasilicate and calcium silicate and a pharmacologically acceptable carrier and a method of preparing the pharmaceutical composition. The oral pharmaceutical composition may be prepared without using a costly special manufacturing system or additive have an off taste masking effect on active ingredients and exhibit an appropriate drug dissolution behavior in the body for manifestation of pharmaceutical effect. Also the oral pharmaceutical composition is compatible with both a water soluble active ingredient and a poorly water soluble active ingredient with high industrial applicability due to simple manufacturing processes and high economical efficiency and productivity. The oral pharmaceutical composition may be formulated in any of a variety of solid dosage forms with improved pharmaceutical characteristics.
