Philip M. Best,Ren-Shiang Chen,Zuojun Lin,Thomas Garcia
申请号：
US12429214
公开号：
US08299211B2
申请日:
2009.04.24
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Calcium channels can be regulated by natural gamma proteins. Herein we disclose embodiments of compositions and methods, particularly involving short peptides which are capable of regulating calcium channel function. Certain short peptides which can inhibit calcium current have structural features from the first transmembrane domain of gamma6 such as a GxxxA motif and adjoining aliphatic residues. In embodiments the peptide compositions and methods are capable of selective efficacy for low voltage-activated calcium channels, such as LVA channel Cav3.1, versus high voltage-activated channels.
