СМИТ Роджер А. (US),ДАМЛЕ Нитин К. (US),ЮРКОВЕЦКИЙ Александр В. (US),ИНЬ Мао (US),ЛОВИНГЕР Тимоти Б. (US),ТОМАС Джошуа Д. (US),СТИВЕНСОН Шери А. (US),ГУРИДЖАЛА Вену Р. (US)
申请号：
RU2016117810
公开号：
RU2016117810A
申请日:
2014.10.10
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.
