1.One pro-drug or its pharmaceutically acceptable salt, the cognate including one drug-connector DL, wherein it includes active part that-D biologies, which are a nitrogen, - L is the sluggish connector of biology a -- fragment of L, and representation formula (I) is combined by forming monamide, wherein the attachment of the nitrogen of the part of dotted line instruction bioactivity X indicates C (RR), N (R), O, C (RR)-C (RR), C (RR)-C (RR), C (RR)-N (R), N (R)-C (RR), C (RR)-O or OC (RR) X b are C or S (O) X b are C (R, R) or C (R, R) -- (R, R) X b are O, S or N-CN R, R, R, R, R, R, R, R, R, R, R, R, R, R are independently selected from the group being made of H and Ci ^ alkyl Optionally,One or more pairs of rear engine/rear wheel drives,Rear engine/rear wheel drive,Rear engine/rear wheel drive,R/Robrazuyut is combined if necessary,One or more pairs of rear engine/rear wheel drives,Rear engine/rear wheel drive,Rear engine/rear wheel drive,Rear engine/rear wheel drive,Rear engine/rear wheel drive,R/Rvmeste with wherein their attached atoms,Optionally it is combined to a naphthenic base or the one or more pairs of rear engine/rear wheel drives of 4-7 circle heterocyclic rings base,Rear engine/rear wheel drive,Rear engine/rear wheel drive,Rear engine/rear wheel drive,Rear engine/rear wheel drive,Rear engine/rear wheel drive,R/Rvmeste with wherein their attached atoms is connected to form a ring and if necessary has the R/Rvmeste for the nitrogen-atoms that wherein they are attached,It is combined to a 4-7 membered heterocyclic rings A is to be made of selected from group the heterobicycle of phenyl, naphthalene, indenyl, indanyl, tetralinyl, naphthenic base, the heterocycle of 4-7- members and 9-11 members Wherein Lzameschen LZ 1-4 grouping and it is optionally further substituted, condition is the hydrogen for being labeled with the symbol * in public formula (I), can by a substituent group gdeLpredstavlyaet replace a singly-bound or a gasket IZ is a group-nositel.
