CYCLODEXTRIN COMPLEXATION METHODS FOR FORMULATING PEPTIDE PROTEASOME INHIBITORS

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专利权人:

INC.;ONYX THERAPEUTICS

发明人:

LEWIS, EVAN,SHWONEK, PETER,DALZIEL, SEAN,JUMAA, MOUHANNAD

申请号：

SG11201407337Q

公开号：

SG11201407337QA

申请日:

2013.05.08

申请国别(地区):

SG

年份:

2014

代理人:

摘要：

This disclosure provides methods for formulating compositions comprising one or more peptide proteasome inhibitors, in particular carfilzomib, and a cyclodextrin, particularly a substituted cyclodextrin. Such methods substantially increase the solubility and stability of these proteasome inhibitors and facilitate both their manufacture and administration.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/