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METHOD FOR STRENGTHENING AN ANTIBODY-DEPENDENT CELL CYTOTOXICITY
专利权人:
ИНК. (US);ВЕНТИРКС ФАРМАСЬЮТИКАЛЗ
发明人:
ХЕРШБЕРГ Роберт (US)
申请号:
RU2012149452/15
公开号:
RU2012149452A
申请日:
2011.04.21
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of increasing antibody-dependent cellular cytotoxicity (ADCC) in a subject receiving treatment with therapeutic monoclonal antibodies, comprising administering to the subject a therapeutic monoclonal antibody and an ADCC enhancing molecule in an amount sufficient to increase ADCC, where the ADCC enhancing molecule is represented by the structure: wherein Y is an aryl ring substituted with C (= O) R, and wherein said aryl ring is optionally further substituted with one or more substituents independently selected from F, Cl, CF, CFO-, HCFO-, C-Calki la, CC heteroalkyl and ArO-; R, R and R are independently selected from H, C-Cialkyl, Ci-alkenyl, Ci-alkyl, Ci-Ci-heteroalkyl, Ci-cycloalkyl, Ci-cycloalkenyl, heterocycloalkyl with from 3 to 8 ring atoms, where one atom is selected from nitrogen, oxygen and sulfur , aryl and 5-7 membered heteroaryl, wherein said alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, aryl and heteroaryl are optionally substituted with one or more substituents independently selected from CCalkyl, CCalkenyl, CCalkynyl, F, Cl, Br , I, CN, OR, NRR, C (= O) R, C (= O) OR, OC (= O) R, C (= O) NRR, (CCalkyl) amino, CHOCHO-, ROC (= O) CH = CH-, NRSOR, SR and SOR; or R and R, together with the atom to which they are attached, form a saturated or partially unsaturated CC carbocyclic ring, wherein said carbocyclic ring is optionally substituted with one or more substituents independently selected from CC alkyl, CC alkenyl, CC alkynyl, F, Cl, Br, I, CN, OR, NRR, C (= O) R, C (= O) OR, OC (= O) R, C (= O) NRR, (CCalkyl) amino, CHOCHO-, ROC (= O) CH = CH -, NRSOR, SR and SOR; R and R are independently selected from H, OR, NRR, CC alkyl, CC alkenyl, CC alkynyl, CC heteroalkyl, CC cycloalkyl, CC cycloalkenyl, heterocycloalkyl with from 3 to 8 ring atoms, where one atom is selected from nitrogen, oxygen1. Способ увеличения антителозависимой клеточной цитотоксичности (ADCC) у субъекта, получающего лечение терапевтически
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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