Methods to Treat or prevent malaria by administration of an inhibitor of Protein Kinase and optionally one or two other protein kinase inhibitor and an anti malaria Drug subject to a Mammal Infected or at risk of exposure to Plasmodium sp.In some respects, Therapeutic and Preventive regimes of this description are effective in reducing the development of parasites in mosquitoes that Feed on the receptors of Regimes in containers of regimes. Additionally, this description provides methods to control anti malaria agents candidates.Claim 1: a method to Treat or prevent malaria Management comprises: a First and a Second Protein Kinase Inhibitor, inhibitor of protein kinase a Mammalian Subject that needs under conditions effective to Treat or prevent malaria. The Method of claim 8: According to any one of claims 1 to 7, where the subject is infected with p.Falciparum, P. vivax, P. ovale, P. malariae and P. knowlesi. The Method of claim 9: According to claim 8, wherein the subject is infected with Chloroquine resistant Plasmodium sp..Claim 13: The Method according to claim 12, wherein the anti malaria Drug comprises one or several additional classes of compounds selected from the group consisting of anti malaria Aminoalcohol, aminoquinolinas, antifolates, polyketide Antibiotics, Sul Fonamidas and others.Claim 32: a method of identifying a compound anti malaria,Comprising: (a) measurement of the activity of a protein kinase Mammalian and mosquito in the presence and Absence of a test compound and (b) the identification of the test compound and a compound anti malaria when it reduces the activity of protein kinase in the presence of Compared with the absence of the test Compound.Claim 37: a method of identifying a compound anti malaria, comprising: (a) comparison of Development or esporozo\u00edtos oocysts in mosquitoes after consumption of a Blood meal comprising Plasmodium sp.In the presence and Absence of a test compound and (b) the identification of the test compound an
